Pharmacological modulation of TNF production in macrophages.

  title={Pharmacological modulation of TNF production in macrophages.},
  author={Hen I Lin and S J Chu and David Daoyi Wang and N Feng},
  journal={Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi},
  volume={37 1},
The quantity and duration of production of tumor necrosis factor (TNF) is tightly controlled due to its potential to cause serious harm. For example, TNF release in response to overwhelming bacterial infection has been implicated as the first step in potentially lethal septic shock. Prostaglandins and leukotrienes are thought to play opposing roles in regulating TNF production by monocytes and macrophages. We investigated the effects of 5 drugs on the production of TNF by cells of the murine… CONTINUE READING