Pharmacological modification of bradykinin induced breakdown of the blood-brain barrier.

@article{Raymond1986PharmacologicalMO,
  title={Pharmacological modification of bradykinin induced breakdown of the blood-brain barrier.},
  author={Jason Raymond and David M. Robertson and Henry B. Dinsdale},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  year={1986},
  volume={13 3},
  pages={214-20}
}
Internal carotid artery infusion of bradykinin caused extensive breakdown of the blood-brain barrier to protein as demonstrated by the extravasation of the marker, horseradish peroxidase, into vessel walls and the adjacent parenchyma. Pretreatment of the animals with indomethacin, trifluoperazine, or imidazole significantly reduced the quantity of abnormally permeable vessels as determined by light microscopy. By electron microscopy, it was determined that bradykinin caused an intense increase… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 48 references

Localization of the central pressoraction of bradykinin to the cerebral third ventricle

RE Lewis, Phillips Ml
Am J Physiol • 1984

Pharmacological modification of blood-brain barrier permeability following a cold lesion.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques • 1984
View 2 Excerpts

Suppression of bradykinin-induced renin release by indomethacin in anesthetized rats.

Clinical and experimental hypertension. Part A, Theory and practice • 1984
View 1 Excerpt

Effects of bradykinin on blood-brain barrier function and pial microcirculation

A Unterberg, M Wahl, A. Baethmann
Advances in Neurosurgery • 1983

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