Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo.

@article{Shukeir2015PharmacologicalMG,
  title={Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo.},
  author={Nicholas Shukeir and Barbara Stefanska and Surabhi Parashar and Farah Alwani Wan Chik and A. K. Arakelian and Moshe Szyf and Shafaat Ahmed Rabbani},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 11},
  pages={
          2769-81
        }
}
BACKGROUND AND PURPOSE DNA hypomethylation was previously implicated in metastasis. In the present study, we examined whether methyl supplementation with the universal methyl donor S-adenosylmethionine (SAM) inhibits prostate cancer associated skeletal metastasis. EXPERIMENTAL APPROACH Highly invasive human prostate cancer cells PC-3 and DU-145 were treated with vehicle alone, S-adenosylhomocysteine (SAH) or SAM and their effects on tumour cell proliferation, invasion, migration and colony… CONTINUE READING
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