Pharmacological mechanisms of clinically favorable properties of a selective beta1-adrenoceptor antagonist, nebivolol.

@article{Kuroedov2004PharmacologicalMO,
  title={Pharmacological mechanisms of clinically favorable properties of a selective beta1-adrenoceptor antagonist, nebivolol.},
  author={Alexey Kuroedov and Francesco Cosentino and Thomas Felix L{\"u}scher},
  journal={Cardiovascular drug reviews},
  year={2004},
  volume={22 3},
  pages={155-68}
}
Nebivolol is a racemic mixture of d- and l-enantiomers. The drug is characterized by beta(1)-adrenoceptor selectivity and long-acting beta-blockade exerted predominantly by d-enantiomer. Nebivolol is devoid of intrinsic sympathomimetic activity and has no relevant membrane stabilizing action. Antiproliferative properties of nebivolol were demonstrated in endothelial and smooth muscle cell cultures. Infusion of nebivolol causes a vasodilation in all vascular beds by endothelial-dependent… CONTINUE READING