Pharmacological mechanisms for left ventricular unloading in clinical congestive heart failure. Differential effects of nitroprusside, phentolamine, and nitroglycerin on cardiac function and peripheral circulation.

@article{Miller1976PharmacologicalMF,
  title={Pharmacological mechanisms for left ventricular unloading in clinical congestive heart failure. Differential effects of nitroprusside, phentolamine, and nitroglycerin on cardiac function and peripheral circulation.},
  author={Randy R Miller and L A Vismara and David O. Williams and Ezra A. Amsterdam and Dean Towle Mason},
  journal={Circulation research},
  year={1976},
  volume={39 1},
  pages={127-33}
}
We compared cardiocirculatory actions of the commonly employed systemic vasodilators, intravenous (iv) nitroprusside (NP), iv phentolamine (PH), and sublingual nitroglycerin (NTG), causing left ventricular (LV) unloading in 29 chronic coronary subjects with congestive failure to determine whether they produce disparate responses in LV function by different relaxing actions on systemic resistance and capacitance beds. Each drug equally lowered systemic arterial pressures to a small extent… CONTINUE READING

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Effect of nitropmsside on left ventricular dynamics in mitral regurgitation

  • RM GoodmanDJ.Rossen, EL Holloway, EL Alderman, DC Harrison
  • Circulation
  • 1974

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