Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells.

Abstract

Viruses have evolved an assortment of mechanisms for regulating the Akt signaling pathway to establish a cellular environment more favorable for viral replication. Myxoma virus (MYXV) is a rabbit-specific poxvirus that encodes many immunomodulatory factors, including an ankyrin repeat-containing host range protein termed M-T5 that functions to regulate… (More)
DOI: 10.1128/JVI.02020-09

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Cite this paper

@article{Werden2010PharmacologicalMO, title={Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells.}, author={Steven J Werden and G. B. McFadden}, journal={Journal of virology}, year={2010}, volume={84 7}, pages={3287-302} }