Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.

@article{Erhardt2009PharmacologicalMO,
  title={Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.},
  author={S Erhardt and Sara K. Olsson and G{\"o}ran Engberg},
  journal={CNS drugs},
  year={2009},
  volume={23 2},
  pages={91-101}
}
The kynurenine pathway constitutes the main route of tryptophan degradation and generates the production of several neuroactive compounds; quinolinic acid is an excitotoxic NMDA receptor agonist, 3-hydroxykynurenine is a free-radical generator and kynurenic acid (KYNA) is an antagonist at glutamate and nicotinic receptors. In low micromolar concentrations, KYNA blocks the glycine site of the NMDA receptor and the nicotinic alpha(7) acetylcholine receptor. Knowledge regarding kynurenine… CONTINUE READING