Pharmacological management of dementia with Lewy bodies with a focus on zonisamide for treating parkinsonism

@article{Panza2020PharmacologicalMO,
  title={Pharmacological management of dementia with Lewy bodies with a focus on zonisamide for treating parkinsonism},
  author={F. Panza and M. Lozupone and Mark I L Watling and B. Imbimbo},
  journal={Expert Opinion on Pharmacotherapy},
  year={2020},
  volume={22},
  pages={325 - 337}
}
ABSTRACT Introduction Dementia with Lewy bodies (DLB) has no approved symptomatic or disease-modifying treatments in the US and Europe, despite being the second most common cause of neurodegenerative dementia. Areas covered Herein, the authors briefly review the DLB drug development pipeline, providing a summary of the current pharmacological intervention studies. They then focus on the anticonvulsant zonisamide, a benzisoxazole derivative with a sulfonamide group and look at its value for… Expand

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TLDR
An overview of the current pharmacotherapy in DLB is provided and potential new drugs are in ongoing clinical trials and it is likely that novel drug targets for the development of better and more effective symptomatic products and disease-modifying therapies are identified. Expand
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