• Corpus ID: 24111474

Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis.

  title={Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis.},
  author={Kenneth L. Davis and Philip A. Berger},
  journal={Biological psychiatry},
  volume={13 1},
  • K. DavisP. Berger
  • Published 1 February 1978
  • Psychology, Medicine
  • Biological psychiatry
The hypotheses of relative cholinergic underactivity in Huntington's disease, tardive dyskinesia, mania, and schizophrenia were pharmacologically investigated, using physostigmine and choline chloride. Intravenous physostigmine improved the involuntary movements of all of four patients with tardive dyskinesia and three of six patients with Huntington's disease. Physostigmine infusion also decreased manic symptoms in six of nine patients with mania, but had no beneficial effects in three… 

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