Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.

@article{Kitani2002PharmacologicalII,
  title={Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.},
  author={Kenichi Kitani and Chiyoko Minami and Takako Yamamoto and Setsuko Kanai and Gwen O. Ivy and M. Belen Carrillo},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={959},
  pages={
          295-307
        }
}
Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species. Pretreatment with the drug for several weeks increases activities of superoxide dismutase (SOD) and catalase (CAT) in selective brain regions. An up-regulation of antioxidant enzyme activities can also be induced in organs such as the heart, kidney, spleen, and adrenal gland, and all are accompanied by an increase in mRNA levels for SODs in… CONTINUE READING

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