Pharmacological interventions for geriatric cachexia: A narrative review of the literature

  title={Pharmacological interventions for geriatric cachexia: A narrative review of the literature},
  author={Alison Yaxley and Michelle D. Miller and Robert J. L. Fraser and Lynne Cobiac},
  journal={The journal of nutrition, health \& aging},
ObjectiveThe objective of this review was to investigate the range of pharmacological interventions that have been studied for treatment of geriatric cachexia, and to evaluate their effect on selected clinical outcomes in this population.MethodsDatabases including Medline and Cochrane Central Register of Controlled Trials were searched up to March 2010 with search terms including “cache*”, “intervention”, “megestrol acetate” and “cytokine inhibitors”. Studies investigating subjects with mean… 
Malnutrition in the elderly : A narrative review
The focus of nutrition is often on healthy diets and exercise to minimise the risk of developing lifestyle diseases such as cancer, diabetes and cardiovascular disease. However, during the shift into
Malnutrition in the elderly: a narrative review.
Older adults should be screened for nutritional issues at diagnosis, on admission to hospitals or care homes and during follow up at outpatient or General Practitioner clinics, at regular intervals depending on clinical status.
Sex‐specific effects of relaxin‐3 on food intake and body weight gain
The overall data suggest a possible role for RLN3 in eating disorders that show a higher propensity in women, and suggests that sex‐specific effects ofRLN3 may also depend on differential expression of RXFP3 receptors in the brain.
Anorexia of aging: A true geriatric syndrome
  • J. Morley
  • Medicine
    The journal of nutrition, health & aging
  • 2012


USAGE of megestrol acetate in the treatment of anorexia-cachexia syndrome in the elderly
There were no significant differences in weight gain between treatment groups, while MA-treated patients reported significantly greater improvement in appetite, enjoyment of life, and well being, while there was no difference in survival between MA and placebo groups.
Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome.
MA is an effective and safe treatment for ACS in cancer and AIDS patients, particularly in terms of improvement in appetite and weight gain, and shows significant benefits over dronabinol in improving appetite.
Quality of life and stimulation of weight gain after treatment with megestrol acetate: correlation between cytokine levels and nutritional status, appetite in geriatric patients with wasting syndrome.
In a geriatric nursing home population with weight loss, reduction in cytokine levels after MA treatment correlates with improvement in appetite, prealbumin, albumin, and improvement in quality of life.
The correlation of cytokine levels with body weight after megestrol acetate treatment in geriatric patients.
  • S. Yeh, S. Y. Wu, +4 authors M. Schuster
  • Medicine
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2001
Reduction in cytokine levels after MA treatment correlated with improvement in weight, fat mass, and FFM at 12 weeks, and significant negative correlation (p < .05) was found.
Megestrol Acetate : A Medical Nutrition Therapy Tool to Effect Positive Weight Outcomes in the Elderly
A prescription medication, megestrol acetate, as an adjunct that might pique an appetite in the elderly population can be a useful adjunct to help the elderly resident gain weight.
Protein and energy supplementation in elderly people at risk from malnutrition.
No evidence of improvement in functional benefit or reduction in length of hospital stay with supplements is found, although Mortality may be reduced in older people who are undernourished.
Cachexia: new advances in the management of wasting diseases.
An International Consensus Conference has recently provided a consensus definition for cachexia and suggested that it should be renamed wasting disease (Figure 1). Approximately half of persons being
A retrospective study of the association between megestrol acetate administration and mortality among nursing home residents with clinically significant weight loss.
MA treatment of elderly nursing home residents with significant weight loss was associated with a significant increase in all-cause mortality without asignificant increase in weight.
Geriatric cachexia: the role of cytokines.
An understanding of the relation between cachexia and negative regulatory cytokines may point to effective treatment of geriatric cachexia, and drugs that promote appetite stimulation and weight gain may work by down-regulating these proinflammatory cytokines.
Epidemiology of weight loss in humans with special reference to wasting in the elderly.
The epidemiology of weight loss in older adults is reviewed with special attention to the problem of cachexia, with potential strategies to help reduce losses in lean body mass and the functional decline that often accompanies weight loss.