Pharmacological interventions for acute bipolar mania: a systematic review of randomized placebo-controlled trials.

@article{Smith2007PharmacologicalIF,
  title={Pharmacological interventions for acute bipolar mania: a systematic review of randomized placebo-controlled trials.},
  author={Lesley A Smith and Victoria Cornelius and Adrian Warnock and Mary Jane Tacchi and David Taylor},
  journal={Bipolar disorders},
  year={2007},
  volume={9 6},
  pages={551-60}
}
OBJECTIVES We conducted a systematic review and meta-analysis of randomized, placebo-controlled trials in acute bipolar mania to summarize available data on drug treatment of mania. METHODS We included trials of medications licensed in the USA or UK for the treatment of any phase of bipolar disorder. Outcomes investigated were changes in mania scores, attrition, extrapyramidal effects and weight change. Data were combined through meta-analyses. RESULTS We included 13 studies (involving 3… CONTINUE READING

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