Pharmacological intervention in invertebrate aging

  title={Pharmacological intervention in invertebrate aging},
  author={Gordon J. Lithgow and Matthew S. Gill and Anders Hval Olsen and James N. Sampayo},
Prompted by successful genetic interventions in aging we now consider the utility of pharmacological interventions. A few clear cases of lifespan extension resulting from exposure to compounds suggest that aging can be slowed and that the pharmacology of lifespan extension is a feasible area for research. Compounds that slow aging may prompt the rational design of therapeutics against age-related diseases. Here we evaluate invertebrate models for drug discovery in aging and outline how the… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
12 Extracted Citations
88 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 12 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 88 references

Oxidative stress

  • JN Sampayo, A Olsen, GJ Lithgow
  • 2003
Highly Influential
4 Excerpts

Extension of life

  • E Bonilla, S Medina-Leendertz, S Diaz
  • 2002
Highly Influential
4 Excerpts

Neuroprotective effects of phenyl

  • JK Kubilus
  • 2005

Neuroprotective effects of phenylbutyrate in the N 17182 Q transgenic mouse model of Huntington ’ s disease

  • G Gardian, SE Browne, DK Choi, P Klivenyi, J Gregorio, JK Kubilus
  • J Biol Chem
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…