Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants.

@article{Villard2011PharmacologicalIW,
  title={Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants.},
  author={Vanessa Villard and Johann Meunier and Nathalie L Chevallier and Tangui Maurice},
  journal={Journal of pharmacological sciences},
  year={2011},
  volume={115 3},
  pages={279-92}
}
Selective agonists of the sigma-1 (σ(1)) ligand-operated chaperone protein, like igmesine or PRE-084, are antidepressants in preclinical depression models. σ(1)-Protein activation may contribute to the antidepressant efficacy of drugs known to act as selective serotonin-reuptake inhibitors (SSRI) or noradrenaline reuptake inhibitors through direct or indirect involvement of the σ(1)-receptor in the drug effect. We here compared antidepressant effects in two behavioral procedures, the forced… CONTINUE READING

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