Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression

@article{Winter2011PharmacologicalIO,
  title={Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression},
  author={Christine Winter and Barbara Vollmayr and Ana{\"i}s Djodari-Irani and Julia Elisabeth Klein and Alexander Sartorius},
  journal={Behavioural Brain Research},
  year={2011},
  volume={216},
  pages={463-465}
}
Identifying new treatment approaches for treatment resistant depression (TRD) is an important topic for translational psychiatry. Functional inhibition of the lateral habenula (LHb) has recently been claimed to offer such an option for TRD. Rats which are bred for high susceptibility to develop learned helplessness provide a genetic model for TRD. We used the gamma-aminobutyric acid agonist muscimol to inhibit the LHb in Sprague-Dawley rats with congenital learned helplessness (cLH… CONTINUE READING
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