Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis.

@article{Wollberg2014PharmacologicalIO,
  title={Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis.},
  author={Anna Ridderstad Wollberg and Anders Ericsson-Dahlstrand and Anders Jur{\'e}us and Petra Ekerot and Sylvia Simon and Maria Nilsson and Stig-Johan Wiklund and Anna-Lena Berg and Mats Ferm and Dan Sunnemark and Rolf Johansson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 14},
  pages={
          5409-14
        }
}
  • Anna Ridderstad Wollberg, Anders Ericsson-Dahlstrand, +8 authors Rolf Johansson
  • Published in
    Proceedings of the National…
    2014
  • Medicine
  • One hallmark of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is infiltration of leukocytes into the CNS, where chemokines and their receptors play a major mediatory role. CX3CR1 is a chemokine receptor involved in leukocyte adhesion and migration and hence a mediator of immune defense reactions. The role of CX3CR1 in MS and EAE pathogenesis however remains to be fully assessed. Here, we demonstrate CX3CR1 mRNA expression on inflammatory cells within active plaque… CONTINUE READING

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