Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.

@article{Baeck2012PharmacologicalIO,
  title={Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.},
  author={Christer Baeck and Alexander Wehr and Karlin Raja Karlmark and Felix Heymann and Mihael Vucur and Nikolaus Gassler and Sebastian Huss and Sven Klussmann and Dirk Eulberg and Tom Luedde and Francisco Javier Cubero and Frank Tacke},
  journal={Gut},
  year={2012},
  volume={61 3},
  pages={416-26}
}
OBJECTIVE Monocyte chemoattractant protein-1 (MCP-1, CCL2), the primary ligand for chemokine receptor C-C chemokine receptor 2 (CCR2), is increased in livers of patients with non-alcoholic steatohepatitis (NASH) and murine models of steatohepatitis and fibrosis. It was recently shown that monocyte/macrophage infiltration into the liver upon injury is critically regulated by the CCL2/CCR2 axis and is functionally important for perpetuating hepatic inflammation and fibrogenesis. The structured L… CONTINUE READING
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