Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models.

@article{Issandou2009PharmacologicalIO,
  title={Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models.},
  author={Marc Issandou and Anne M Bouillot and J M Brusq and Marie-Claire Forest and Didier Grillot and Raphaelle Guillard and Sandrine L Martin and Christelle Michiels and Thierry Sulpice and Alain Daugan},
  journal={European journal of pharmacology},
  year={2009},
  volume={618 1-3},
  pages={28-36}
}
Stearoyl-CoA Desaturase 1 (SCD1) is a central enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. SCD1 is an emerging target in obesity and insulin resistance due to the improved metabolic profile obtained when the enzyme is genetically inactivated. Here, we have investigated if the pharmacological inhibition of SCD1 could elicit the same profile. We have identified a small molecule, GSK993 and characterized it as a potent and orally available SCD1… CONTINUE READING
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