Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.

@article{Kim2015PharmacologicalIO,
  title={Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.},
  author={Jinu Kim and Sang Pil Yoon and Myron L. Toews and John D. Imig and Sung Hee Hwang and Bruce D Hammock and Babu J Padanilam},
  journal={American journal of physiology. Renal physiology},
  year={2015},
  volume={308 2},
  pages={F131-9}
}
Treating chronic kidney disease (CKD) has been challenging because of its pathogenic complexity. Epoxyeicosatrienoic acids (EETs) are cytochrome P-450-dependent derivatives of arachidonic acid with antihypertensive, anti-inflammatory, and profibrinolytic functions. We recently reported that genetic ablation of soluble epoxide hydrolase (sEH), an enzyme that… CONTINUE READING