Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections.

  title={Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections.},
  author={Morten Hentzer and Michael Givskov},
  journal={The Journal of clinical investigation},
  volume={112 9},
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. Compounds able… CONTINUE READING
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