Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes.

  title={Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes.},
  author={Christian J Carlson and C. Rondinone},
  journal={Metabolism: clinical and experimental},
  volume={54 7},
  • Christian J Carlson, C. Rondinone
  • Published 2005
  • Biology, Medicine
  • Metabolism: clinical and experimental
  • Inhibition of p38, a member of the mitogen-activated protein kinase family, has been shown to prevent the loss of GLUT4 protein expression in insulin-resistant adipocytes without improving insulin receptor substrate 1 (IRS-1) protein levels and presumably insulin signaling. Thus, it was unclear whether p38 inhibitors would have a beneficial effect upon insulin-stimulated glucose uptake. We evaluated the effects of p38 inhibition during the development of insulin resistance upon glucose uptake… CONTINUE READING
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