Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes.

@article{Carlson2005PharmacologicalIO,
  title={Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes.},
  author={Christian J Carlson and C. Rondinone},
  journal={Metabolism: clinical and experimental},
  year={2005},
  volume={54 7},
  pages={
          895-901
        }
}
  • Christian J Carlson, C. Rondinone
  • Published 2005
  • Biology, Medicine
  • Metabolism: clinical and experimental
  • Inhibition of p38, a member of the mitogen-activated protein kinase family, has been shown to prevent the loss of GLUT4 protein expression in insulin-resistant adipocytes without improving insulin receptor substrate 1 (IRS-1) protein levels and presumably insulin signaling. Thus, it was unclear whether p38 inhibitors would have a beneficial effect upon insulin-stimulated glucose uptake. We evaluated the effects of p38 inhibition during the development of insulin resistance upon glucose uptake… CONTINUE READING
    20 Citations

    Topics from this paper

    Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes
    • 10
    Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes
    • 62
    • PDF
    Role of MKK3–p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice
    • 80
    • PDF

    References

    SHOWING 1-10 OF 21 REFERENCES
    Rapamycin partially prevents insulin resistance induced by chronic insulin treatment.
    • 72
    MKK6/3 and p38 MAPK Pathway Activation Is Not Necessary for Insulin-induced Glucose Uptake but Regulates Glucose Transporter Expression*
    • 129
    • Highly Influential
    • PDF
    Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.
    • 119
    Specific Inhibitors of p38 Mitogen-activated Protein Kinase Block 3T3-L1 Adipogenesis*
    • 342
    • PDF
    A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation*
    • 137
    • Highly Influential
    • PDF
    IRS proteins and the common path to diabetes.
    • M. White
    • Biology, Medicine
    • American journal of physiology. Endocrinology and metabolism
    • 2002
    • 837
    • PDF
    Signaling Pathways Mediating Insulin‐Stimulated Glucose Transport
    • 98