Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis.

@article{Patsenker2009PharmacologicalIO,
  title={Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis.},
  author={Eleonora Patsenker and Yury V Popov and Felix Stickel and Vreni Schneider and Monika Ledermann and Hans Saegesser and Gerald U. Niedobitek and Simon L Goodman and Detlef B Schuppan},
  journal={Hepatology},
  year={2009},
  volume={50 5},
  pages={1501-11}
}
UNLABELLED The vitronectin receptor integrin alphavbeta3 promotes angiogenesis by mediating migration and proliferation of endothelial cells, but also drives fibrogenic activation of hepatic stellate cells (HSCs) in vitro. Expecting antifibrotic synergism, we studied the effect of alphavbeta3 inhibition in two in vivo models of liver fibrogenesis. Liver fibrosis was induced in rats by way of bile duct ligation (BDL) for 6 weeks or thioacetamide (TAA) injections for 12 weeks. A specific… CONTINUE READING

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