Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

  title={Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.},
  author={Veerle Rottiers and Susanna Obad and Andreas Petri and Robert W. McGarrah and Marie Wickstr{\"o}m Lindholm and Joshua Black and Sumita Sinha and Robin J. Goody and Matthew S Lawrence and Andrew S Delemos and Henrik Frydenlund Hansen and Steve Whittaker and Steve Henry and Rohn Brookes and Seyed Hani Najafi-Shoushtari and Raymond Tsang Chi Chung and Johnathan R. Whetstine and Robert E. Gerszten and Sakari Kauppinen and Anders M. N{\"a}{\"a}r},
  journal={Science translational medicine},
  volume={5 212},
MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base pairing with 3' untranslated regions, primarily via seed sequences (nucleotides 2 to 8 in the mature miRNA sequence). A number of individual miRNAs and miRNA families share seed sequences and targets, but differ in the sequences outside of the seed. miRNAs have been implicated in the etiology of a wide variety of human diseases and therefore represent promising… CONTINUE READING
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