Pharmacological inhibition of Mannheimia haemolytica lipopolysaccharide and leukotoxin-induced cytokine expression in bovine alveolar macrophages.

@article{Malazdrewich2004PharmacologicalIO,
  title={Pharmacological inhibition of Mannheimia haemolytica lipopolysaccharide and leukotoxin-induced cytokine expression in bovine alveolar macrophages.},
  author={C Malazdrewich and Praveen Thumbikat and Mitchell S. Abrahamsen and Samuel K. Maheswaran},
  journal={Microbial pathogenesis},
  year={2004},
  volume={36 3},
  pages={159-69}
}
The inflammatory cytokines tumor necrosis factor-alpha (TNFalpha), interleukin-1 beta (IL-1beta), and interleukin-8 (IL-8) are believed to contribute to the pathogenesis of lung injury in bovine pneumonic mannheimiosis (BPM) caused by Mannheimia (Pasteurella) haemolytica. Inflammatory cytokines may, therefore, represent therapeutic targets to be modulated… CONTINUE READING