Pharmacological inhibition of EZH2 disrupts the female germline epigenome

Abstract

Recently discovered drugs that target epigenetic modifying complexes are providing new treatment options for a range of cancers that affect patients of reproductive age. Although these drugs provide new therapies, it is likely that they will also affect epigenetic programming in sperm and oocytes. A promising target is Enhancer of Zeste 2 (EZH2), which… (More)
DOI: 10.1186/s13148-018-0465-4

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