Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.


The aim of the present study was to investigate the therapeutic effects of pharmacological inhibition of DDAH1 (dimethylarginine dimethylaminohydrolase 1), an enzyme that metabolizes endogenously produced nitric oxide synthase inhibitors, principally ADMA (asymmetric dimethylarginine). The present study employs a series of rodent models to evaluate the… (More)
DOI: 10.1042/BJ20131666


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