Pharmacological induction of the 70-kDa heat shock protein protects against brain injury

@article{Kim2015PharmacologicalIO,
  title={Pharmacological induction of the 70-kDa heat shock protein protects against brain injury},
  author={Nuri Kim and Jong Youl Kim and Midori A Yenari},
  journal={Neuroscience},
  year={2015},
  volume={284},
  pages={912-919}
}
The 70-kDa heat shock protein (HSP70) is known to protect the brain from injury through multiple mechanisms. We investigated the effect of pharmacological HSP70 induction in experimental traumatic brain injury (TBI). 3-month-old male C57/B6 mice were given 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) intraperitoneally (IP, 2 mg/kg) or intracerebroventricularly (ICV, 1 μg/kg) to determine whether HSP70 could be induced in the brain. Mice were subjected to TBI via cortical controlled impact… CONTINUE READING
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