Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone-preferring receptors.

@article{Dallman1989PharmacologicalET,
  title={Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone-preferring receptors.},
  author={Mary F. Dallman and Nancy Levin and C S Cascio and Susan F. Akana and Lisa A Jacobson and Robert W. Kuhn},
  journal={Endocrinology},
  year={1989},
  volume={124 6},
  pages={2844-50}
}
These studies were performed to determine pharmacologically the corticosteroid receptor type that mediates the effects of corticosterone (B) on ACTH secretion in adrenalectomized rats. We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B, dexamethasone (DEX), or aldosterone (ALDO) in doses that elevated plasma levels to concentrations in the range between 0.2-30 nM. Plasma ACTH, corticosteroid-binding globulin (CBG), and… CONTINUE READING

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We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B , dexamethasone ( DEX ) , or aldosterone ( ALDO ) in doses that elevated plasma levels to concentrations in the range between 0.2 - 30 nM. Plasma ACTH , corticosteroid - binding globulin ( CBG ) , and thymus weight were measured in the morning or evening , and these steroid - sensitive end points were related to the circulating concentrations of B ( total B - CBG - bound B ) , total DEX , and total ALDO .
Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone - preferring receptors .
These studies were performed to determine pharmacologically the corticosteroid receptor type that mediates the effects of corticosterone ( B ) on ACTH secretion in adrenalectomized rats .
By contrast , DEX was 3 times more potent than B on CBG ( estimated IC50 , 1.5 and 4.5 nM , respectively ) and tended to be more effective on thymus weight , suggesting that the effects of corticosteroids on these peripheral targets are mediated by association of the steroids with type II glucocorticoid receptors .
We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B , dexamethasone ( DEX ) , or aldosterone ( ALDO ) in doses that elevated plasma levels to concentrations in the range between 0.2 - 30 nM. Plasma ACTH , corticosteroid - binding globulin ( CBG ) , and thymus weight were measured in the morning or evening , and these steroid - sensitive end points were related to the circulating concentrations of B ( total B - CBG - bound B ) , total DEX , and total ALDO .
The rank order of potency for B and DEX on ACTH and the agreement between the steady state IC50 values achieved for these steroids and the Kd values determined for B and DEX with type I receptors in vitro strongly suggest that feedback control of basal diurnal ACTH by corticosteroids is mediated by association with type I , B - preferring receptors .
By contrast , DEX was 3 times more potent than B on CBG ( estimated IC50 , 1.5 and 4.5 nM , respectively ) and tended to be more effective on thymus weight , suggesting that the effects of corticosteroids on these peripheral targets are mediated by association of the steroids with type II glucocorticoid receptors .
We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B , dexamethasone ( DEX ) , or aldosterone ( ALDO ) in doses that elevated plasma levels to concentrations in the range between 0.2 - 30 nM. Plasma ACTH , corticosteroid - binding globulin ( CBG ) , and thymus weight were measured in the morning or evening , and these steroid - sensitive end points were related to the circulating concentrations of B ( total B - CBG - bound B ) , total DEX , and total ALDO .
The rank order of potency for B and DEX on ACTH and the agreement between the steady state IC50 values achieved for these steroids and the Kd values determined for B and DEX with type I receptors in vitro strongly suggest that feedback control of basal diurnal ACTH by corticosteroids is mediated by association with type I , B - preferring receptors .
By contrast , DEX was 3 times more potent than B on CBG ( estimated IC50 , 1.5 and 4.5 nM , respectively ) and tended to be more effective on thymus weight , suggesting that the effects of corticosteroids on these peripheral targets are mediated by association of the steroids with type II glucocorticoid receptors .
By contrast , DEX was 3 times more potent than B on CBG ( estimated IC50 , 1.5 and 4.5 nM , respectively ) and tended to be more effective on thymus weight , suggesting that the effects of corticosteroids on these peripheral targets are mediated by association of the steroids with type II glucocorticoid receptors .
We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B , dexamethasone ( DEX ) , or aldosterone ( ALDO ) in doses that elevated plasma levels to concentrations in the range between 0.2 - 30 nM. Plasma ACTH , corticosteroid - binding globulin ( CBG ) , and thymus weight were measured in the morning or evening , and these steroid - sensitive end points were related to the circulating concentrations of B ( total B - CBG - bound B ) , total DEX , and total ALDO .
The rank order of potency for B and DEX on ACTH and the agreement between the steady state IC50 values achieved for these steroids and the Kd values determined for B and DEX with type I receptors in vitro strongly suggest that feedback control of basal diurnal ACTH by corticosteroids is mediated by association with type I , B - preferring receptors .
We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B , dexamethasone ( DEX ) , or aldosterone ( ALDO ) in doses that elevated plasma levels to concentrations in the range between 0.2 - 30 nM. Plasma ACTH , corticosteroid - binding globulin ( CBG ) , and thymus weight were measured in the morning or evening , and these steroid - sensitive end points were related to the circulating concentrations of B ( total B - CBG - bound B ) , total DEX , and total ALDO .
The rank order of potency for B and DEX on ACTH and the agreement between the steady state IC50 values achieved for these steroids and the Kd values determined for B and DEX with type I receptors in vitro strongly suggest that feedback control of basal diurnal ACTH by corticosteroids is mediated by association with type I , B - preferring receptors .
By contrast , DEX was 3 times more potent than B on CBG ( estimated IC50 , 1.5 and 4.5 nM , respectively ) and tended to be more effective on thymus weight , suggesting that the effects of corticosteroids on these peripheral targets are mediated by association of the steroids with type II glucocorticoid receptors .
By contrast , DEX was 3 times more potent than B on CBG ( estimated IC50 , 1.5 and 4.5 nM , respectively ) and tended to be more effective on thymus weight , suggesting that the effects of corticosteroids on these peripheral targets are mediated by association of the steroids with type II glucocorticoid receptors .
We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B , dexamethasone ( DEX ) , or aldosterone ( ALDO ) in doses that elevated plasma levels to concentrations in the range between 0.2 - 30 nM. Plasma ACTH , corticosteroid - binding globulin ( CBG ) , and thymus weight were measured in the morning or evening , and these steroid - sensitive end points were related to the circulating concentrations of B ( total B - CBG - bound B ) , total DEX , and total ALDO .
The rank order of potency for B and DEX on ACTH and the agreement between the steady state IC50 values achieved for these steroids and the Kd values determined for B and DEX with type I receptors in vitro strongly suggest that feedback control of basal diurnal ACTH by corticosteroids is mediated by association with type I , B - preferring receptors .
We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B , dexamethasone ( DEX ) , or aldosterone ( ALDO ) in doses that elevated plasma levels to concentrations in the range between 0.2 - 30 nM. Plasma ACTH , corticosteroid - binding globulin ( CBG ) , and thymus weight were measured in the morning or evening , and these steroid - sensitive end points were related to the circulating concentrations of B ( total B - CBG - bound B ) , total DEX , and total ALDO .
Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone - preferring receptors .
These studies were performed to determine pharmacologically the corticosteroid receptor type that mediates the effects of corticosterone ( B ) on ACTH secretion in adrenalectomized rats .
By contrast , DEX was 3 times more potent than B on CBG ( estimated IC50 , 1.5 and 4.5 nM , respectively ) and tended to be more effective on thymus weight , suggesting that the effects of corticosteroids on these peripheral targets are mediated by association of the steroids with type II glucocorticoid receptors .
By contrast , DEX was 3 times more potent than B on CBG ( estimated IC50 , 1.5 and 4.5 nM , respectively ) and tended to be more effective on thymus weight , suggesting that the effects of corticosteroids on these peripheral targets are mediated by association of the steroids with type II glucocorticoid receptors .
We have compared the effects of treating young male rats at the time of adrenalectomy and throughout the next 5 days with B , dexamethasone ( DEX ) , or aldosterone ( ALDO ) in doses that elevated plasma levels to concentrations in the range between 0.2 - 30 nM. Plasma ACTH , corticosteroid - binding globulin ( CBG ) , and thymus weight were measured in the morning or evening , and these steroid - sensitive end points were related to the circulating concentrations of B ( total B - CBG - bound B ) , total DEX , and total ALDO .
The rank order of potency for B and DEX on ACTH and the agreement between the steady state IC50 values achieved for these steroids and the Kd values determined for B and DEX with type I receptors in vitro strongly suggest that feedback control of basal diurnal ACTH by corticosteroids is mediated by association with type I , B - preferring receptors .
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