Pharmacological evidence that alpha1-and alpha2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs.

@article{Willems1999PharmacologicalET,
  title={Pharmacological evidence that alpha1-and alpha2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs.},
  author={Edwin W. Willems and M Trion and P. Nouwens T. de Vries and Jan P. C. Heiligers and Carlos M Villal{\'o}n and Pramod R. Saxena},
  journal={British journal of pharmacology},
  year={1999},
  volume={127 5},
  pages={1263-71}
}
Vasoconstriction of carotid arteriovenous anastomoses may be involved in the therapeutic action of acutely acting anti-migraine agents, including the triptans and ergot alkaloids. While 5-HT1B/1D receptors mediate the effect of triptans, ergotamine and dihydroergotamine also interact with alpha-adrenoceptors. In the present study, we investigated the potential role of alpha1- and alpha2-adrenoceptors in mediating vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs. Ten… CONTINUE READING