Pharmacological evidence that 5-HT(1B/1D) receptors mediate hypotension in anesthetized rats.

@article{Terrn2007PharmacologicalET,
  title={Pharmacological evidence that 5-HT(1B/1D) receptors mediate hypotension in anesthetized rats.},
  author={Jos{\'e} Antonio Terr{\'o}n and Carolina S{\'a}nchez-Maldonado and Esther Mart{\'i}nez-Garc{\'i}a},
  journal={European journal of pharmacology},
  year={2007},
  volume={576 1-3},
  pages={132-5}
}
5-Carboxamidotryptamine (5-CT; 0.003-310 microg/kg, i.v.) produced dose-dependent hypotensive responses which were blocked in a complex manner by the 5-HT(7) receptor antagonist, (R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl) ethyl] pyrrolidine (SB-269970; 1 mg/kg, i.v.), in anesthetized vagosympathectomized rats. Interestingly, the 5-HT(1B/1D) receptor antagonist, N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1-biphenyl]-4… CONTINUE READING