Pharmacological evidence of the stimulation of central alpha-adrenergic receptors

  title={Pharmacological evidence of the stimulation of central alpha-adrenergic receptors},
  author={P. Simon and R. Chermat and A. Puech},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • P. Simon, R. Chermat, A. Puech
  • Published 31 December 1983
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
We studied the interactions between CRL 40028 (benzhydryl sulfinyl) acetohydroxamic acid) and the alpha 1 blocker prazosin, in mouse. CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse. 
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