Pharmacological evidence of the stimulation of central alpha-adrenergic receptors

@article{Simon1983PharmacologicalEO,
  title={Pharmacological evidence of the stimulation of central alpha-adrenergic receptors},
  author={P. Simon and R. Chermat and A. Puech},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1983},
  volume={7},
  pages={183-186}
}
  • P. Simon, R. Chermat, A. Puech
  • Published 31 December 1983
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
We studied the interactions between CRL 40028 (benzhydryl sulfinyl) acetohydroxamic acid) and the alpha 1 blocker prazosin, in mouse. CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse. 
Behavioral models in mice. implication of the alpha noradrenergic system
TLDR
It was found that clonidine, an Alpha 2 agonist, acted differently according to the test used, and provoked sedation in spontaneous activity test, and anti-immobility effects in the other tests. Expand
Pharmacological analysis of the hypothermic effects of NAN-190 and its analogs, postsynaptic 5-HT1A receptor antagonists, in mice.
TLDR
The obtained results suggest that the hypothermia in mice induced by NAN-190 and its constrained analog MP245 is connected with stimulation of 5-HT1A receptors and with blockade of alpha1-adrenoceptors, participation of these receptors not being equivalent, though. Expand
Evidence that 5-HT2A receptors are not involved in 5-HT-mediated thermoregulation in mice
TLDR
It is suggested that in mice, 5-HT2A receptors are unlikely to be involved in 5- HT-mediated thermoregulation. Expand
Additive effects of clonidine and antidepressant drugs in the mouse forced-swimming test
TLDR
In the mouse forced-swimming model, dose-dependent reversal of immobility was induced by the alpha-agonist clonidine given IP 30 min before testing, and one effect of antide-pressants might be the triggering of different relationships between alpha-2 and 5-HT mechanisms. Expand
Modafinil, A Unique Wake-Promoting Drug: A Serendipitous Discovery in Search of a Mechanism of Action
Modafinil, a unique wake-promoting drug, resulted from a serendipitous discovery when, in the 1970s, the Research Department of Laboratoire Louis Lafon was focused on the discovery ofExpand
Adrafinil: A Novel Vigilance Promoting Agent
Behavioral stimulants have widespread potential application in the treatment of affective disorders, disorders of vigilance, and disorders of sleep. Most behavioral stimulants, however, must be usedExpand
On the treatment of the alcoholic organic brain syndrome with an alpha-adrenergic agonist modafinil: double-blind, placebo-controlled clinical, psychometric and neurophysiological studies
TLDR
Considering the beneficial effects of modafinil in abstinent chronic alcoholic patients, it may be said that activation and improvement of adaptive behaviour by an alpha-adrenergic agonist could be regarded as a therapeutic principle in the treatment of the OBS, eventually due to noradrenaline deficits. Expand
CNS Drug Reviews
Behavioral stimulants have widespread potential application in the treatment of affective disorders, disorders of vigilance, and disorders of sleep. Most behavioral stimulants, however, must be usedExpand
Pharmacology of stimulants prohibited by the World Anti‐Doping Agency (WADA)
  • J. Docherty
  • Psychology, Medicine
  • British journal of pharmacology
  • 2008
TLDR
This review examines the pharmacology of stimulants prohibited by the World Anti‐Doping Agency, including drugs like ephedrine available in many over‐the‐counter medicines and agents with abuse potential as recreational drugs. Expand
Adrafinil disrupts performance on a delayed nonmatching-to-position task in aged beagle dogs
TLDR
Treatment with 20 mg/kg of adrafinil produced a significant impairment in working memory as indicated by an increase in the number of errors over the 8-day test period, which could be a result of increased noradrenergic transmission in the prefrontal cortex. Expand
...
1
2
...

References

SHOWING 1-6 OF 6 REFERENCES
A possibe alpha-adrenergic mechanism for drug (CRL 40028)-induced hyperactivity.
TLDR
Results suggest that stimulation of an alpha-adrenergic postsynaptic receptor is of importance for the stimulant effect of CRL 40028. Expand
The interaction between prazosin and clonidine at α-adrenoceptors in rats and cats
TLDR
The clonidine-induced reduction of the tachycardia evoked in pithed rats by electrical stimulation of cardiac sympathetic nerve fibres was antagonized by piperoxan and less effectively by prazosin, thus suggesting that prazoin displays a modest degree of cardiac presynaptic α-adrenoceptor blocking activity apart from its predominantly postsynaptic affinity. Expand
Anticonvulsant effect of yohimbine in quaking mice: antagonism by clonidine and prazosine.
TLDR
Yohimbine has a protective action on the convulsive seizures induced in quaking mice by tactile stimulation and is antagonized by prior administration of clonidine or prazosine. Expand
SIXTH GADDUM MEMORIAL LECTURE NATIONAL INSTITUTE FOR MEDICAL RESEARCH, MILL HILL, JANUARY 1977
  • S. Langer
  • Medicine
  • British journal of pharmacology
  • 1977
TLDR
The topic of the lecture will be the presence of presynaptic receptors in noradrenergic nerve endings and their role in the regulation of the release of the neurotransmitter upon arrival of nerve impulses. Expand