Pharmacological evidence for the role of nitric oxide in the modulation of stress-induced anxiety by morphine in rats.

Abstract

The present study evaluated the effects of the opioid agonist, morphine on stress induced anxiogenesis and the possible involvement of nitric oxide (NO) in such effects in rats. Acute restraint stress consistently induced an anxiety-like response in the elevated plus maze test, i.e. reduced number of open arm entries and time spent in the open arms as… (More)
DOI: 10.1016/j.ejphar.2011.11.032

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