Pharmacological evidence for the presence of three distinct functional endothelin receptor subtypes in the rabbit lateral saphenous vein.

@article{Douglas1995PharmacologicalEF,
  title={Pharmacological evidence for the presence of three distinct functional endothelin receptor subtypes in the rabbit lateral saphenous vein.},
  author={Stephen A. Douglas and Gary R. Beck and John D. Elliott and Eliot H. Ohlstein},
  journal={British journal of pharmacology},
  year={1995},
  volume={114 8},
  pages={1529-40}
}
1. Contraction of the rabbit isolated saphenous vein is mediated by a heterogeneous endothelin (ET) receptor population. This study has characterized these receptor subtypes by use of several pharmacologically distinct ET receptor agonists and antagonists. 2. ET-1, ET-3, sarafotoxin S6c (STXc) and [Ala3,11]ET-1 produced biphasic, concentration-dependent contractions of the saphenous vein, responses which were best fitted by a two-site model comprised of a high (pM) and a low (nM) affinity site… CONTINUE READING

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