Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of adenosine in the mouse forced swimming test.

@article{Kaster2007PharmacologicalEF,
  title={Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of adenosine in the mouse forced swimming test.},
  author={Manuella Pinto Kaster and Josiane Budni and Adair Roberto Soares dos Santos and Ana L{\'u}cia S Rodrigues},
  journal={European journal of pharmacology},
  year={2007},
  volume={576 1-3},
  pages={91-8}
}
This study investigated the involvement of the opioid system in the antidepressant-like effect of adenosine in the forced swimming test. The effect of adenosine (10 mg/kg, i.p.) was prevented by the pretreatment of mice with naloxone (1 mg/kg, i.p., a nonselective opioid receptor antagonist), naltrindole (3 mg/kg, i.p., a selective delta-opioid receptor antagonist), clocinnamox (1 mg/kg, i.p., an irreversible mu-opioid receptor antagonist), and 2-(3,4-dichlorophenyl)-Nmethyl-N-[(1S)-1-(3… CONTINUE READING