Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release.

@article{Hashimotodani2008PharmacologicalEF,
  title={Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release.},
  author={Yuki Hashimotodani and Takako Ohno-Shosaku and Takashi Maejima and Kiyoko Fukami and Masanobu Kano},
  journal={Neuropharmacology},
  year={2008},
  volume={54 1},
  pages={58-67}
}
Depolarization-induced suppression of inhibition (DSI) or excitation (DSE) is a well-known form of endocannabinoid-mediated short-term plasticity that is induced by postsynaptic depolarization. It is generally accepted that DSI/DSE is triggered by Ca(2+) influx through voltage-gated Ca(2+) channels. It is also demonstrated that DSI/DSE is mediated by 2-arachidonoylglycerol (2-AG). However, how Ca(2+) induces 2-AG production is still unclear. In the present study, we investigated molecular… CONTINUE READING