Pharmacological evidence for the activation of K(+) channels by diclofenac.

  title={Pharmacological evidence for the activation of K(+) channels by diclofenac.},
  author={Mario I Ortiz and Jorge El{\'i}as Torres-L{\'o}pez and Gilberto Casta{\~n}eda-Hern{\'a}ndez and Rodolfo Rosas and Guadalupe C Vidal-Cant{\'u} and Vinicio Granados-Soto},
  journal={European journal of pharmacology},
  volume={438 1-2},
The involvement of K(+) channels in the antinociceptive action of diclofenac was assessed in the formalin test. Local administration of diclofenac produced a dose-dependent antinociceptive effect due to a local action because drug administration in the contralateral paw was ineffective. Pretreatment of the injured paw with glibenclamide and tolbutamide (ATP-sensitive K(+) channel inhibitors), charybdotoxin and apamin (large- and small-conductance Ca(2+)-activated K(+) channel blockers… CONTINUE READING