Pharmacological evidence for distinct endothelin receptors in guinea-pig bronchus and aorta.

  • D. W. P. Hay
  • Published 1992 in British journal of pharmacology


The ETA receptor antagonist, BQ-123 (1 microM) potently antagonized endothelin-1 (ET-1) concentration-response curves in guinea-pig aorta (pKB = 7.1). However, 10 microM BQ-123 was without effect on ET-1-induced contractions in guinea-pig bronchus. The ETB-selective agonist, sarafotoxin S6c did not contract the aorta but was a potent and effective… (More)


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