Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat.

@article{Buerkle1998PharmacologicalEF,
  title={Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat.},
  author={Hartmut Buerkle and Tony L. Yaksh},
  journal={British journal of anaesthesia},
  year={1998},
  volume={81 2},
  pages={208-15}
}
Alpha2-adrenergic agonists given intrathecally result in antinociception and intracerebroventricularly (ICV) in sedation. To examine whether different alpha2-adrenergic receptor subtypes differentially mediate antinociception and sedation, we measured the relative potency of three alpha2-adrenergic agonists, dexmedetomidine (DMET), clonidine (CLON) and UK-14.304 (UK), after spinal and ICV administration. Each agonist was given either alone or in the presence of systemically administered… CONTINUE READING
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