Corpus ID: 38393576

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.

@article{Walker2008PharmacologicalEF,
  title={Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.},
  author={B. Walker and G. Koob},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={2008},
  volume={33 3},
  pages={
          643-52
        }
}
  • B. Walker, G. Koob
  • Published 2008
  • Medicine
  • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
The purpose of this study was to test the hypothesis that activation of the dynorphin/kappa (kappa)-opioid system has a role in the increased consumption of ethanol in dependent animals. The effects of three opioid receptor antagonists with different effects on opioid receptors, naltrexone, nalmefene, and nor-binaltorphimine (nor-BNI), were compared in their ability to decrease ethanol self-administration in nondependent and ethanol-dependent male Wistar rats. Nalmefene and naltrexone are both… Expand
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