Pharmacological evaluation of purified component and whole-cell pertussis vaccine in the cardiovascular system of rats.

The present study compares the cardiovascular activity of a newly introduced and possibly safer acellular pertussis vaccine with that of a conventional whole-cell pertussis vaccine. The vasodilation that occurs after beta-2 adrenoceptor stimulation with salbutamol, as well as the negative chronotropic action induced by the muscarinic receptor stimulant… CONTINUE READING