Pharmacological evaluation of ethanolic extract of Daucus carota Linn root formulated cream on wound healing using excision and incision wound model

@article{Patil2012PharmacologicalEO,
  title={Pharmacological evaluation of ethanolic extract of Daucus carota Linn root formulated cream on wound healing using excision and incision wound model},
  author={Mithun Vishwanath K. Patil and Amit D Kandhare and Sucheta D. Bhise},
  journal={Asian pacific Journal of Tropical Biomedicine},
  year={2012},
  volume={2}
}
Abstract Objective Daucus carota L. (Carrot) (Apiaceae) is used in the traditional medicine for the treatment of variety of ailments. [...] Key Method Excision wounds sized 300 mm 2 and 2 mm depth were used for the study of rate of contraction of wound and epithelization at different time intervals. Incision wounds six centimeter long and two linear-paravertebral incisions were used for the study of tensile strength, total protein and hydroxyproline content measured on 10th day old incision wound.Expand
Extracts of Tridax procumbens linn leaves causes wound healing in diabetic and Non-diabetic laboratory animals
TLDR
The findings confirmed the ethanomedicinal claim of Tridax procumbens(L.) in wound healing in diabetic and nondiabetic conditions. Expand
A topical ointment formulation containing leaves’ powder of Lawsonia inermis accelerate excision wound healing in Wistar rats
TLDR
Treatment with LI has shown excellent wound healing activity, and the histological findings that revealed better epithelialization, dermal differentiation, collagen fiber orientation, and angiogenesis in LI treated rats compared to control are supported. Expand
Pharmacological Evaluation of Topical Gel Containing Plant Proteinases on Wound Healing Using Excision and Incision Wound
The aim of present study was to evaluate wound healing activity of topical gel containing plant proteinases using excision and incision wound model. In excision wound model, Circular wounds of aboutExpand
WOUND HEALING ACTIVITY OF THE LEAVES OF Artocarpus heterophyllus Lam. (Moraceae) ON ex-vivo PORCINE SKIN WOUND HEALING MODEL
ABSTRACT Objective: To prescreen the ex- vivo wound healing activity of flavonoid rich fraction of ethyl acetate extract of the leaves of Artocarpus heterophyllus Lam. Family Moraceae using porcineExpand
HEALING ACTIVITY OF LEPIDIUM SATIVUM L. IN EXPERIMENTALLY INDUCED DIABETIC RATS.
TLDR
Ethanolic seed extract of Lepidium sativum is effective in treatment of diabetic wounds and may be attributed to its antihyperglycaemic and anti-inflammatory property. Expand
Croton urucurana Baillon stem bark ointment accelerates the closure of cutaneous wounds in knockout IL-10 mice.
TLDR
The groups treated with CR1 and CR2 ointments presented higher rate of wound closure, increased total number of cells, mast cells, blood vessels and higher deposition of type III and I collagen, which support the popular use of preparations based on the bark of C. urucurana as a healing compound. Expand
Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats
TLDR
NOF exerts wound healing potential via down-regulated expression of inflammatory, TNF-α, and ILs, apoptotic (pol-γ and Bax), and up-regulated growth factor (VEGF and TGF-β) expression, thus modulating collagen-1 expression to induce angiogenesis leading to wound healing. Expand
Hydroalcoholic extract from Lepidium meyenii (Black Maca) root exerts wound healing activity in Streptozotocin-induced diabetic rats
TLDR
This is the first report on wound healing properties of BME in diabetic rats and shows a significant difference in the rate of wound contraction, wound index, dry and wet granulation weights, and concentration of hydroxyproline and hexosamine contents. Expand
Betel Leaf Extract Efficacy on Wound Healing: A Systematic review
TLDR
Betel leaf extract has the potential to heal wounds both acute wounds, infection wounds and diabetic ulcers and is effective in the inflammatory phase, proliferation and remodeling of wound healing phases. Expand
Effect of aqueous extract of Cucumis sativus Linn. fruit in ulcerative colitis in laboratory animals
TLDR
The present investigation demonstrates C. sativus is of potent therapeutic value in the amelioration of experimental colitis in laboratory animals by inhibiting the inflammatory mediator. Expand
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Enhanced wound contraction, decreased epithelialization time, increased hydroxyproline content and histological characteristics suggest that noni leaf extract may have therapeutic benefits in wound healing. Expand
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The present investigation demonstrates that by virtue of its antioxidant property and presence of the flavanoids content in C. sativus may responsible for wound contraction and elevated rate of epithelization in wound healing in laboratory animals. Expand
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It is concluded that formulating J. curcas -based herbal ointment formulations in wound repair will stimulate commercial interest in harnessing this plant as an ingredient for the production of topical preparations and should be explored in exploring the potentials of the plant in the treatment of topical diseases. Expand
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The result shows that TDR extract ointment demonstrates wound healing potential in both excision and incision models. Expand
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The experimental data demonstrated that Arnebia densiflora displayed remarkable wound healing activity, which supported the outcome of both incision and excision wound models. Expand
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TLDR
It is possible to conclude that this plant has wound healing activity and there by justifying traditional claim, because the efficacy of Achillea millefolium L. in wound healing may be due to the presence of active principles, which accelerate the healing process and confers breaking strength to the healed wound. Expand
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