Pharmacological evaluation of an epoxide as the putative hyperpolarizing factor mediating the nitric oxide-independent vasodilator effect of bradykinin in the rat heart.

@article{Fulton1998PharmacologicalEO,
  title={Pharmacological evaluation of an epoxide as the putative hyperpolarizing factor mediating the nitric oxide-independent vasodilator effect of bradykinin in the rat heart.},
  author={D Fulton and J C Mcgiff and J Quilley},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 2},
  pages={497-503}
}
  • D Fulton, J C Mcgiff, J Quilley
  • Published 1998 in
    The Journal of pharmacology and experimental…
A cytochrome P450-derived metabolite of arachidonic acid, namely an epoxyeicosatrienoic acid (EET), has many of the properties of a hyperpolarizing factor that mediates endothelium-dependent, nitric oxide-independent vasodilation. As there are four EET regioisomers, we used pharmacological criteria, based on previous observations with bradykinin (BK), to evaluate which, if any, of the EETs could be considered a potential mediator of vasodilator responses to BK in the rat isolated heart treated… CONTINUE READING
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