Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential.

@article{Alberati2010PharmacologicalEO,
  title={Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential.},
  author={Daniela Alberati and J. V. Moreau and Roland Mory and Emmanuel Pinard and Joseph G. Wettstein},
  journal={Pharmacology, biochemistry, and behavior},
  year={2010},
  volume={97 2},
  pages={185-91}
}
Multiple lines of evidence support the notion that hypofunction of glutamatergic neurotransmission is involved in the pathophysiology of schizophrenia. Moreover, glycine and glycine modulators have beneficial effects in patients with schizophrenia, particularly when added on to existing therapy. As glycine is an obligatory co-agonist at the NR1 subunit of the NMDA receptor, blockade of glycine uptake at the glycine transporter type-1 (GlyT1) can enhance low glutamatergic tone. L-687,414 is an… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
6 Extracted Citations
0 Extracted References
Similar Papers

Similar Papers

Loading similar papers…