Pharmacological evaluation of JO 1870: relation to the potential treatment of urinary bladder incontinence.

@article{Soulard1992PharmacologicalEO,
  title={Pharmacological evaluation of JO 1870: relation to the potential treatment of urinary bladder incontinence.},
  author={Claire Soulard and Xavier B. Pascaud and François J. Roman and Agnes Grouhel and Jean Louis Junien},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={260 3},
  pages={
          1152-8
        }
}
The effect of p.o. administered JO 1870 [(-)-1-(p-chlorophenyl)-N,N- dimethyl-1-ethyl(4-phenyl)-but-3-en-1-ylamine, hydrochloride] on the urinary bladder cystometrogram has been investigated in the unanesthetized rat. The effects of JO 1870 have been compared with those of morphine and reference drugs currently used for the treatment of urinary incontinence in humans. JO 1870 (2.5-25 mg/kg) dose-dependently increased the bladder capacity and the threshold pressure responsible for urination… CONTINUE READING