Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons

Abstract

Inhibitors of kynurenine 3-hydroxylase have previously been used to increase endogenous levels of kynurenic acid, an excitatory amino acid receptor antagonist. In the present electrophysiological study PNU 156561A was utilized to elevate endogenous concentrations of kynurenic acid and subsequent effects on the firing pattern of dopamine (DA) neurons of rat… (More)
DOI: 10.1007/s007260170032

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@article{Erhardt2001PharmacologicalEO, title={Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons}, author={S Erhardt and Henrik {\"{O}berg and Jan M. Math{\'e} and G{\"{o}ran Engberg}, journal={Amino Acids}, year={2001}, volume={20}, pages={353-362} }