Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis.

@article{Pittelli2011PharmacologicalEO,
  title={Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis.},
  author={Maria Rosa Pittelli and Roberta Felici and Vanessa Pitozzi and Lisa Giovannelli and Elisabetta Bigagli and Francesca Cialdai and Giovanni Romano and Flavio Moroni and Alberto Chiarugi},
  journal={Molecular pharmacology},
  year={2011},
  volume={80 6},
  pages={1136-46}
}
During the last several years, evidence that various enzymes hydrolyze NAD into bioactive products prompted scientists to revisit or design strategies able to increase intracellular availability of the dinucleotide. However, plasma membrane permeability to NAD and the mitochondrial origin of the dinucleotide still wait to be clearly defined. Here, we report that intracellular NAD contents increased upon exposure of cell lines or primary cultures to exogenous NAD (eNAD). NAD precursors could not… CONTINUE READING