Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics.

@article{Christensen1984PharmacologicalEO,
  title={Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics.},
  author={Anne Vibeke Christensen and J\orn Arnt and John Hyttel and Jens J\orgen Larsen and Ove Svendsen},
  journal={Life sciences},
  year={1984},
  volume={34 16},
  pages={
          1529-40
        }
}
Neuroleptics such as thioxanthenes (cis(Z)-flupentixol and cis(Z)-clopenthixol) and phenothiazines (fluphenazine and perphenazine), which block both dopamine (DA) D-1 and D-2 receptors and the butyrophenones (haloperidol and spiroperidol), which block D-2 receptors only, are equipotent both behaviorally and clinically. A new compound SCH 23390 which selectively blocks DA D-1 receptors, resembles many neuroleptics in its pharmacological profile: antistereotypic effects in mice, rats and dogs… CONTINUE READING
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