• Chemistry, Medicine
  • Published in
    The Journal of pharmacology…
    1998

Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models.

@article{Jackson1998PharmacologicalEO,
  title={Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models.},
  author={Jeffery R. Jackson and Brian J. Bolognese and L. Hillegass and Shouki Kassis and Jessica Adams and Don Edgar Griswold and James D. Winkler},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={284 2},
  pages={
          687-92
        }
}
Chronic inflammatory diseases often are accompanied by intense angiogenesis, supporting the destructive proliferation of inflammatory tissues. A model of inflammatory angiogenesis is the murine air pouch granuloma, which has a hyperangiogenic component. In this model, we explored the regulation of inflammatory angiogenesis using SB 220025, a specific inhibitor of human p38 mitogen-activated protein (MAP) kinase, with an IC50 value of 60 nM and 50- to 1000-fold selectivity vs. other kinases… CONTINUE READING

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