Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5‐HT2 receptors

@article{Dudley1988PharmacologicalEO,
  title={Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5‐HT2 receptors},
  author={Mark W. Dudley and Norbert L. Wiech and Francis P. Miller and Albert Anthony Carr and Hsien Chang Cheng and Lawrence E. Roebel and Niall Stephen Doherty and Henry I. Yamamura and Richard C. Ursillo and Michael G. Palfreyman},
  journal={Drug Development Research},
  year={1988},
  volume={13}
}
MDL 11,939 (α‐phenyl‐1‐(2‐phenylethyl)‐4‐piperidine methanol) has been shown, through in vitro studies utilizing radioligand binding and isolated tissues as well as through in vivo tests of central and peripheral serotonergic activity, to be a potent, selective antagonist at 5‐hydroxytryptamine receptors of the 5‐HT2 subtype. In particular, MDL 11,939 shows low affinity for the 5‐HT1 and 5‐HT3 subtypes of the serotonin receptor and displays low or negligible affinity for alpha adrenergic… 

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