Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum.

@article{Maixner1981PharmacologicalEO,
  title={Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum.},
  author={William Maixner and Stephen Arneric and M S Abou Zeit-Har and J Lecompte and T. Verimer and Joseph Gerard Cannon and T. Lee and John Paul Long},
  journal={European journal of pharmacology},
  year={1981},
  volume={71 4},
  pages={
          475-82
        }
}
9 Citations
ANTAGONISM OF PRE AND POSTSYNAPTIC α‐ADRENORECEPTORS BY BE 2254 (HEAT) AND PRAZOSIN
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It was concluded that BE 2254 is a potent antagonist at presynaptic alpha 2-adrenoreceptors in vitro and in vivo, and at postsynaptic alpha 1-ad Renoreceptor in vitro, but has only weak activity at vascular post synapse-induced vasoconstriction in the pithed rat.
α2‐Adrenoceptor agonist properties of exo‐ and endo‐isomers of 2‐amino‐6,7,dihydroxybenzo‐norbornene designed as rigid catecholamines
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Important conformational requirements for the interaction of catecholamines at presynaptic or postsynaptic α2‐receptors are demonstrated, and it is suggested that a fully extended or anti‐conformation of the noradrenaline molecule is involved in α 2‐receptor‐agonist interaction.
Inhibition of Insulin Release from Rat Pancreatic Islets by Drugs that Are Analogues of Dopamine
TLDR
Data show that selective dopamine agonists, such as RDS-127, reduce glucose-stimulated insulin release indirectly through adrenal medullary secretions, whereas the effect of less selective agonism directly inhibit the release of insulin from the endocrine pancreas.

References

SHOWING 1-10 OF 23 REFERENCES
Pharmacology of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99). I. Cardiovascular activity in the dog and cat.
TLDR
A detailed study of these compounds showed that they were most likely exerting their effects by inhibiting sympathetic nervous system activity.
Inhibition of the sympathetic nervous system by 5,6-dihydroxy-2-dimethylamino tetralin (M-7), apomorphine and dopamine.
TLDR
It is postulated that prejunctional sympathetic nerves innervating the heart have dopamine receptors that serve as inhibitory role in transmission.
Mechanism of the antihypertensive action of clonidine on the pressor response to physostigmine.
TLDR
Physostigmine was used as a model in anesthetized rats for the development of hypertension by a central cholinergic mechanism and clonidine significantly reduced turnover in hypothalamus, pons-medulla, midbrain and midbrain but not in striatum or hippocampus, consistent with an inhibitory effect ofClonidine on central choline neurons involved in cardiovascular regulation.
Congeners of the beta conformer of dopamine derived from cis- and trans-octahydrobenzo[f]quinoline and trans-octahydrobenzo[g]quinoline.
TLDR
R rigid congeners of the beta conformer derived from linearly and angularly annelated octahydrobenzoquinolines have been synthesized and present a clear separation of CNS effects from some potent peripheral effects.
Acetylcholine release from guinea‐pig ileum by parasympathetic ganglion stimulants and gastrin‐like polypeptides
  • E. Vizi
  • Biology, Chemistry
    British journal of pharmacology
  • 1973
TLDR
The data suggest the presence in the parasympathetic ganglion cells of separate gastrointestinal hormone‐sensitive receptors in the guinea‐pig longitudinal muscle strip, which is mediated via α‐adrenoceptors since phentolamine prevented its action.
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