Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum.

@article{Maixner1981PharmacologicalEO,
  title={Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum.},
  author={William Maixner and Stephen Arneric and M S Abou Zeit-Har and J Lecompte and T. Verimer and Joseph Gerard Cannon and T. Lee and John Paul Long},
  journal={European journal of pharmacology},
  year={1981},
  volume={71 4},
  pages={
          475-82
        }
}
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9 Citations

9 Citations

α1/α2-Adrenoceptor agonist selectivity of mono- and dihydroxy-2-N,N-di-n-propylaminotetralins
Interaction of dihydroxy-2-aminotetralin derivatives at sites labelled with [3H]clonidine, [3H]prazosin and [3H]spiperone in rat brain membranes.
ANTAGONISM OF PRE AND POSTSYNAPTIC α‐ADRENORECEPTORS BY BE 2254 (HEAT) AND PRAZOSIN
TLDR
It was concluded that BE 2254 is a potent antagonist at presynaptic alpha 2-adrenoreceptors in vitro and in vivo, and at postsynaptic alpha 1-ad Renoreceptor in vitro, but has only weak activity at vascular post synapse-induced vasoconstriction in the pithed rat.
Antagonist properties of phentolamine at both presynaptic alpha 2-adrenoceptors and presynaptic dopamine receptors using field stimulated right cat atria.
α2‐Adrenoceptor agonist properties of exo‐ and endo‐isomers of 2‐amino‐6,7,dihydroxybenzo‐norbornene designed as rigid catecholamines
TLDR
Important conformational requirements for the interaction of catecholamines at presynaptic or postsynaptic α2‐receptors are demonstrated, and it is suggested that a fully extended or anti‐conformation of the noradrenaline molecule is involved in α 2‐receptor‐agonist interaction.
Inhibition of Insulin Release from Rat Pancreatic Islets by Drugs that Are Analogues of Dopamine
TLDR
Data show that selective dopamine agonists, such as RDS-127, reduce glucose-stimulated insulin release indirectly through adrenal medullary secretions, whereas the effect of less selective agonism directly inhibit the release of insulin from the endocrine pancreas.
The central sympatho-inhibitory effect of 5,6-dihydroxy-2-dimethylaminotetralin (M7) is mediated by alpha 2-adrenoceptors.
A paradoxical stimulatory effect of berberine on guinea-pig ileum contractility: possible involvement of acetylcholine release from the postganglionic parasympathetic nerve and cholinesterase inhibition.
Noradrenergic inhibition of the nicotinically-stimulated release of acetylcholine from guinea-pig ileal synaptosomes.

References

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    British journal of pharmacology
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TLDR
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